Issues

In this issue Sukhoplyasova and colleagues (pp. 1459–1473) report that Lhs1-dependent substrates share a unique set of features. Their data provide hints as to the identities of as-yet unconfirmed substrates of Lhs1 and potentially of the Lhs1 homolog in mammals, GRP170. The cover image is a structural model of the ENaC transmembrane domains (αENaC purple, βENaC gold and γENaC teal). Space filling models indicate predicted, polar inter-subunit interactions. Image courtesy of Teresa M. Buck.