Atherosclerosis is a chronic inflammatory disease associated with lipid metabolism disorder. Autophagy is a catabolic process and contributes to maintaining cellular homeostasis. Substantial evidence suggests that defective autophagy is implicated in several diseases, including atherosclerosis, while increased autophagy mitigates atherosclerosis development. Thus, understanding the mechanisms of autophagy regulation and its association with atherosclerosis is vital to develop new therapies against atherosclerosis. Dietary bioactive compounds are non-nutrient natural compounds that include phenolics, flavonoids, and carotenoids. Importantly, these bioactive compounds possess anti-inflammatory, antioxidant, and antibacterial properties that may alleviate various chronic diseases. Recently, examining the effects of bioactive compounds on autophagy activity in atherogenesis has drawn considerable attention. The current review discusses the role of macrophage autophagy in the development and progression of atherosclerosis. We also summarize our current knowledge of the therapeutic potential of bioactive compounds on atherosclerosis and autophagy.
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Cover Image
In this issue, Lee and colleagues (pp. 1471–1484) demonstrate a new mechanism for tau secretion potentially involved in neurodegenerative disease progression, involving syntaxins (STX) 6 and 8. The cover image shows immunostaining of primary mouse neurons transfected with eGFP-STX6 (green) and human V5-tau (red) with co-localization of V5-tau and eGFP-STX6 in secretory vesicles. Superimposed is a schematic illustrating the proposed transmembrane transfer of tau via STX6/8 TM, STX6 or STX8 into the trans-Golgi network (TGN) or recycling endosomes (RE) for subsequent secretion. The cover image was provided by Lars M Ittner.
Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds
MD Khurshidul Zahid, Hazera Binte Sufian, Mahua Choudhury, Masao Yamasaki, Ahmed Al-Harrasi, Naima Moustaid-Moussa, Shaikh Mizanoor Rahman; Role of macrophage autophagy in atherosclerosis: modulation by bioactive compounds. Biochem J 16 April 2021; 478 (7): 1359–1375. doi: https://doi.org/10.1042/BCJ20200894
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