Signaling pathways play critical roles in regulating the activation of T cells. Recognition of foreign peptide presented by MHC to the T cell receptor (TCR) triggers a signaling cascade of proximal kinases and adapter molecules that lead to the activation of Effector kinase pathways. These effector kinase pathways play pivotal roles in T cell activation, differentiation, and proliferation. RNA sequencing-based methods have provided insights into the gene expression programs that support the above-mentioned cell biological responses. The proteome is often overlooked. A recent study by Damasio et al. [Biochem. J. (2021) 478, 79–98. doi:10.1042/BCJ20200661] focuses on characterizing the effect of extracellular signal-regulated kinase (ERK) on the remodeling of the proteome of activated CD8+ T cells using Mass spectrometric analysis. Surprisingly, the Effector kinase ERK pathway is responsible for only a select proportion of the proteome that restructures during T cell activation. The primary targets of ERK signaling are transcription factors, cytokines, and cytokine receptors. In this commentary, we discuss the recent findings by Damasio et al. [Biochem. J. (2021) 478, 79–98. doi:10.1042/BCJ20200661] in the context of different Effector kinase pathways in activated T cells.
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Cover Image
The chart featured in this issue's cover of Biochemical Journal (volume 478, issue 6) depicts a novel non-canonical amylin trafficking pathway to the cell nucleus including its accumulation in an unexpected intracellular compartment, the cell nucleolus. The 3D LSCM micrograph features DAPI-stained nucleus (blue) and amylin assemblies (green) in the two nucleoli (arrowheads). Read more about transcriptional and trafficking mechanisms of human islet amyloid polypeptide in the research piece by Bhowmick et al.
T cells: a dedicated effector kinase pathways for every trait?
Kriti Bahl, Jeroen P. Roose; T cells: a dedicated effector kinase pathways for every trait?. Biochem J 26 March 2021; 478 (6): 1303–1307. doi: https://doi.org/10.1042/BCJ20210006
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