Calcium (Ca2+) signaling is a versatile signaling network in plant and employs very efficient signal decoders to transduce the encoded message. The CBL–CIPK module is one of the sensor-relay decoders that have probably evolved with the acclimatization of land plant. The CBLs are unique proteins with non-canonical Ca2+ sensing EF-hands, N-terminal localization motif and a C-terminal phosphorylation motif. The partner CIPKs are Ser/Thr kinases with kinase and regulatory domains. Phosphorylation plays a major role in the functioning of the module. As the module has a functional kinase to transduce signal, it employs phosphorylation as a preferred mode for modulation of targets as well as its interaction with CBL. We analyze the data on the substrate regulation by the module from the perspective of substrate phosphorylation. We have also predicted some of the probable sites in the identified substrates that may be the target of the CIPK mediated phosphorylation. In addition, phosphatases have been implicated in reversing the CIPK mediated phosphorylation of substrates. Therefore, we have also presented the role of phosphatases in the modulation of the CBL–CIPK and its targets. We present here an overview of the phosphoregulation mechanism of the CBL–CIPK module.
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March 2020
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Native electrospray ionization mass spectrometry revealed coronaviral polyprotein processing by the viral protease and subsequent complex formation. For further information, see the article by Kirchel and colleagues (pp. 1009–1019) in this issue. The image was in parts created by Anne Rupprecht (Rostock, Germany) and compiled by Boris Krichel. Image provided by Charlotte Uetrecht.
Review Article|
March 04 2020
CBL–CIPK module-mediated phosphoregulation: facts and hypothesis
Sibaji K. Sanyal;
Sibaji K. Sanyal
Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India
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Swati Mahiwal;
Swati Mahiwal
Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India
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Deepti M. Nambiar;
Deepti M. Nambiar
Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India
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Girdhar K. Pandey
Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India
Correspondence: Girdhar K. Pandey (gkpandey@south.du.ac.in)
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Publisher: Portland Press Ltd
Received:
December 26 2019
Revision Received:
February 10 2020
Accepted:
February 11 2020
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2020
Biochem J (2020) 477 (5): 853–871.
Article history
Received:
December 26 2019
Revision Received:
February 10 2020
Accepted:
February 11 2020
Citation
Sibaji K. Sanyal, Swati Mahiwal, Deepti M. Nambiar, Girdhar K. Pandey; CBL–CIPK module-mediated phosphoregulation: facts and hypothesis. Biochem J 13 March 2020; 477 (5): 853–871. doi: https://doi.org/10.1042/BCJ20190339
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