Much attention has recently been focussed on the lysosome as a signalling hub. Following the initial discovery that localisation of the nutrient-sensitive kinase, mammalian target of rapamycin complex 1 (mTORC1), to the lysosome was essential for mTORC1 activation, the field has rapidly expanded to reveal the role of the lysosome as a platform permitting the co-ordination of several homeostatic signalling pathways. Much is now understood about how the lysosome contributes to amino acid sensing by mTORC1, the involvement of the energy-sensing kinase, AMP-activated protein kinase (AMPK), at the lysosome and how both AMPK and mTORC1 signalling pathways feedback to lysosomal biogenesis and regeneration following autophagy. This review will cover the classical role of the lysosome in autophagy, the dynamic signalling interactions which take place on the lysosomal surface and the multiple levels of cross-talk which exist between lysosomes, AMPK and mTORC1.
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May 2017
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Cover Image
3D reconstructions of 4 individual Escherichia coli cells that have been serially sectioned and immunolabelled to unambiguously identify a membrane protein of interest (TatA, position marked by spheres). The reconstructions illustrate a linear clustering of TatA protein in the inner membrane of E. coli – a previously uncharacterised distribution for this protein. For more information, please see article by Sarah M. Smith et al, pages 1495–1508. Image provided by Sarah M. Smith.
Review Article|
April 13 2017
The lysosome: a crucial hub for AMPK and mTORC1 signalling
Bernadette Carroll;
Bernadette Carroll
1Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, U.K.
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Elaine A. Dunlop
2Division of Cancer and Genetics, Cardiff University, Cardiff, U.K.
Correspondence: Elaine A. Dunlop (dunlopea@cardiff.ac.uk)
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Publisher: Portland Press Ltd
Received:
January 16 2017
Revision Received:
February 21 2017
Accepted:
February 27 2017
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2017
Biochem J (2017) 474 (9): 1453–1466.
Article history
Received:
January 16 2017
Revision Received:
February 21 2017
Accepted:
February 27 2017
Citation
Bernadette Carroll, Elaine A. Dunlop; The lysosome: a crucial hub for AMPK and mTORC1 signalling. Biochem J 1 May 2017; 474 (9): 1453–1466. doi: https://doi.org/10.1042/BCJ20160780
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