Advances in next-generation sequencing technologies continue to unravel the cancer genome, identifying key biological pathways important for disease pathogenesis and clinically relevant genetic lesions. These studies have provided unprecedented resolution of the cancer genome, facilitating significant advances in the ability to detect many cancers, and predict patients who will develop an aggressive disease or respond poorly to treatment. The mature B-cell neoplasm chronic lymphocytic leukaemia remains at the forefront of these genomic analyses, largely due its protracted natural history and the accessibility to suitable material for study. We now possess a comprehensive view of the genomic copy number mutational landscape of the disease, as well as a detail description of clonal evolution, and the molecular mechanisms that drive the acquisition of genomic lesions and more broadly, genomic complexity. Here, recent genomic insights with associated biological and clinical implications will be reviewed.
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November 2016
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From untargeted plasma metabolomics from carriers affected with the FMR1 premutation and control subjects, putative target proteins were identified which were used as input data to build a protein-protein interaction network. Please see pp. 3871–3888 for further information. Image provided by C. Guilivi.
Review Article|
October 27 2016
The mutational signature of chronic lymphocytic leukemia
Helen Parker;
Helen Parker
Cancer Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, U.K.
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Jonathan C. Strefford
Jonathan C. Strefford
Cancer Genomics, Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, U.K.
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Publisher: Portland Press Ltd
Received:
March 23 2016
Revision Received:
August 23 2016
Accepted:
August 23 2016
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society
2016
Biochem J (2016) 473 (21): 3725–3740.
Article history
Received:
March 23 2016
Revision Received:
August 23 2016
Accepted:
August 23 2016
Citation
Helen Parker, Jonathan C. Strefford; The mutational signature of chronic lymphocytic leukemia. Biochem J 1 November 2016; 473 (21): 3725–3740. doi: https://doi.org/10.1042/BCJ20160256
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