We present crystal structures of a trimeric coiled-coil domain found in echinoderm microtubule (MT)-associated protein (EMAP)-like (EML) proteins. This trimerization domain (TD) mediates self-association and interactions between a subset of EML proteins. MT-association of EML proteins requires the TD and an adjacent basic region.

Keywords:
crystal structure, coiled-coil, echinoderm microtubule-associated protein-like (EML)1, echinoderm microtubule-associated protein-like (EML)2, echinoderm microtubule-associated protein-like–anaplastic lymphoma kinase (EML4–ALK), microtubule
© The Authors Journal compilation © 2015 Biochemical Society
2015
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