In this study we demonstrate that ischemia-induced impairment of intercellular communication between cardiomyocytes is due to the degradation of the gap junction protein Connexin43 by autophagy, which according to the severity of the insult involves different molecular partners.

Keywords:
autophagy, cardiomyocyte, Cx43, gap junction, ischaemia
© The Authors Journal compilation © 2015 Biochemical Society
2015
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