We show that ATP-binding cassette protein 50, which binds eukaryotic initiation factor-2, plays a key role in translation initiation. ATPase-defective mutants of ABC50 usurp the accuracy of the recognition of start codons, suggesting it helps ensure the accuracy of initiation.

Keywords:
translation initiation, eIF2, ABCF1, start codon, accuracy, initiation factor
© The Authors Journal compilation © 2015 Biochemical Society
2015
You do not currently have access to this content.