Factor Va competes factor Xa off of inactive factor Xa dimers to amplify thrombin production, both because it releases dimer inhibition and because of its cofactor activity. This suggests an unanticipated mechanism by which platelet membranes can regulate blood coagulation.

Keywords:
calcium, coagulation, dimerization, factor Xa, factor Va, prothrombinase complex
© The Authors Journal compilation © 2015 Biochemical Society
2015
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