MUC1 is a transmembrane mucin highly expressed in the stomach. Although extensive research has uncovered many of its roles in cancer, knowledge about the functions of MUC1 in normal tissues is limited. In the present study, we showed that acetylsalicylic acid (ASA; aspirin) up-regulated MUC1/Muc1 expression in the gastric mucosa of humans and wild-type (WT) mice. ASA induced mucosal injury in all mice to a similar extent; however, WT animals and those chimaeras with Muc1 on the epithelia recovered faster than Muc1-knockout (KO) mice and chimaeras carrying Muc1 on haemopoietic but not epithelial cells. MUC1 enhanced proliferation and migration of the human gastric cell line MKN-7 and increased resistance to apoptosis. The repeated treatment regime used caused a reduction in cyclo-oxygenase-1 (Cox-1) expression, though WT animals returned faster towards pre-treatment levels and had increased Cox-2 and vascular endothelial growth factor levels during recovery. Thus we found that epithelial Muc1 is more important for the healing process than haemopoietic Muc1 and Muc1/MUC1 facilitates wound healing by enhancing cell migration and proliferation, protecting against apoptosis and mediating expression of mucosal modulators. Thus MUC1 plays essential roles during wound healing and development of treatment modalities targeting enhanced expression of MUC1 may be beneficial to treat mucosal wounds.
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February 2015
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Research Article|
January 22 2015
Epithelial MUC1 promotes cell migration, reduces apoptosis and affects levels of mucosal modulators during acetylsalicylic acid (aspirin)-induced gastropathy
Debashish Banerjee;
Debashish Banerjee
*Department of Biomedical Chemistry and Cell Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden
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Harvey Robert Fernandez;
Harvey Robert Fernandez
1
*Department of Biomedical Chemistry and Cell Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden
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Pradeep Bhatu Patil;
Pradeep Bhatu Patil
1
†Laboratory for Transplantation and Regenerative Medicine, University of Gothenburg, SE-405 30 Gothenburg, Sweden
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Pushpa Premaratne;
Pushpa Premaratne
*Department of Biomedical Chemistry and Cell Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden
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Marianne Quiding-Järbrink;
Marianne Quiding-Järbrink
§Department of Microbiology and Immunology, University of Gothenburg, SE-405 30 Gothenburg, Sweden
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Sara Katarina Lindén
Sara Katarina Lindén
2
*Department of Biomedical Chemistry and Cell Biology, University of Gothenburg, SE-405 30 Gothenburg, Sweden
2To whom correspondence should be addressed (email sara.linden@biomedicine.gu.se).
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Publisher: Portland Press Ltd
Received:
May 22 2014
Revision Received:
November 04 2014
Accepted:
November 11 2014
Accepted Manuscript online:
November 11 2014
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2015 Biochemical Society
2015
Biochem J (2015) 465 (3): 423–431.
Article history
Received:
May 22 2014
Revision Received:
November 04 2014
Accepted:
November 11 2014
Accepted Manuscript online:
November 11 2014
Citation
Debashish Banerjee, Harvey Robert Fernandez, Pradeep Bhatu Patil, Pushpa Premaratne, Marianne Quiding-Järbrink, Sara Katarina Lindén; Epithelial MUC1 promotes cell migration, reduces apoptosis and affects levels of mucosal modulators during acetylsalicylic acid (aspirin)-induced gastropathy. Biochem J 1 February 2015; 465 (3): 423–431. doi: https://doi.org/10.1042/BJ20140617
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