For some time now it has been known that diabetes and atherosclerosis are chronic inflammatory diseases that are closely associated with one another and often develop together. In both there is an increase in tissue-wide inflammation that is exhibited by the infiltration of immune cells into the adipose tissue and the vascular walls respectively. The monocyte/macrophage populations that are recruited in these seemingly different settings also display a high similarity by exhibiting similar phenotypes in both conditions. In the insulin resistant as well as the atherosclerotic setting there is a distinct switch in the macrophage populations present from an anti-inflammatory (M2) population to an inflammatory (M1) population, which releases cytokines and chemotactic factors with the ability to worsen the local environment and thus aggravate the situation by creating a vicious circle. However, although some discoveries suggest that preventing the development of M1 macrophages reduces inflammation and thereby aggravation of these diseases, there are currently no clear-cut opinions on how to achieve a switch from M2 to M1.
Skip Nav Destination
Article navigation
August 2013
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
Review Article|
July 26 2013
Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes
Robert Stöhr;
Robert Stöhr
1Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Search for other works by this author on:
Massimo Federici
Massimo Federici
1
1Department of Systems Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
1To whom correspondence should be addressed (email federicm@uniroma2.it).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
January 22 2013
Revision Received:
May 14 2013
Accepted:
June 03 2013
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem J (2013) 454 (1): 1–11.
Article history
Received:
January 22 2013
Revision Received:
May 14 2013
Accepted:
June 03 2013
Citation
Robert Stöhr, Massimo Federici; Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes. Biochem J 15 August 2013; 454 (1): 1–11. doi: https://doi.org/10.1042/BJ20130121
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.