PMPs (peroxisome membrane proteins) play essential roles in organelle biogenesis and in co-ordinating peroxisomal metabolism with pathways in other subcellular compartments through transport of metabolites and the operation of redox shuttles. Although the import of soluble proteins into the peroxisome matrix has been well studied, much less is known about the trafficking of PMPs. Pex3 and Pex19 (and Pex16 in mammals) were identified over a decade ago as critical components of PMP import; however, it has proved surprisingly difficult to produce a unified model for their function in PMP import and peroxisome biogenesis. It has become apparent that each of these peroxins has multiple functions and in the present review we focus on both the classical and the more recently identified roles of Pex19 and Pex3 as informed by structural, biochemical and live cell imaging studies. We consider the different models proposed for peroxisome biogenesis and the role of PMP import within them, and propose that the differences may be more perceived than real and may reflect the highly dynamic nature of peroxisomes.
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Review Article|
April 12 2013
Peroxisome membrane proteins: multiple trafficking routes and multiple functions?
Frederica L. Theodoulou;
Frederica L. Theodoulou
1
*Biological Chemistry and Crop Protection Department, Rothamsted Research, Harpenden AL5 2JQ, U.K.
1To whom correspondence should be addressed (email freddie.theodoulou@rothamsted.ac.uk).
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Kristin Bernhardt;
Kristin Bernhardt
†Institut für Biochemie der Pflanzen, Heinrich-Heine Universität Düsseldorf, D-40225 Düsseldorf, Germany
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Nicole Linka;
Nicole Linka
†Institut für Biochemie der Pflanzen, Heinrich-Heine Universität Düsseldorf, D-40225 Düsseldorf, Germany
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Alison Baker
Alison Baker
‡Centre for Plant Sciences, School of Biology, University of Leeds, Leeds LS2 9JT, U.K.
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Publisher: Portland Press Ltd
Received:
January 14 2013
Revision Received:
February 18 2013
Accepted:
February 19 2013
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2013 Biochemical Society
2013
Biochem J (2013) 451 (3): 345–352.
Article history
Received:
January 14 2013
Revision Received:
February 18 2013
Accepted:
February 19 2013
Citation
Frederica L. Theodoulou, Kristin Bernhardt, Nicole Linka, Alison Baker; Peroxisome membrane proteins: multiple trafficking routes and multiple functions?. Biochem J 1 May 2013; 451 (3): 345–352. doi: https://doi.org/10.1042/BJ20130078
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