The RSK (90 kDa ribosomal S6 kinase) family comprises a group of highly related serine/threonine kinases that regulate diverse cellular processes, including cell growth, proliferation, survival and motility. This family includes four vertebrate isoforms (RSK1, RSK2, RSK3 and RSK4), and single family member orthologues are also present in Drosophila and Caenorhabditis elegans. The RSK isoforms are downstream effectors of the Ras/ERK (extracellular-signal-regulated kinase) signalling pathway. Significant advances in the field of RSK signalling have occurred in the past few years, including several new functions ascribed to the RSK isoforms, the discovery of novel protein substrates and the implication of different RSK isoforms in cancer. Collectively, these new findings increase the diversity of biological functions regulated by RSK, and highlight potential new directions of research. In the present paper, we review the structure, expression and activation mechanisms of the RSK isoforms, and discuss their physiological roles on the basis of established substrates and recent discoveries.
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January 2012
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Review Article|
December 21 2011
Regulation and function of the RSK family of protein kinases
Yves Romeo;
Yves Romeo
†Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, P.O. Box 6128, Montreal, QC, Canada, H3C 3J7
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Xiaocui Zhang;
Xiaocui Zhang
†Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, P.O. Box 6128, Montreal, QC, Canada, H3C 3J7
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Philippe P. Roux
Philippe P. Roux
1
†Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, P.O. Box 6128, Montreal, QC, Canada, H3C 3J7
‡Department of Pathology and Cell Biology, Faculty of Medicine, Université de Montréal, P.O. Box 6128, Montreal, QC, Canada, H3C 3J7
1To whom correspondence should be addressed (email philippe.roux@umontreal.ca).
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Publisher: Portland Press Ltd
Received:
February 14 2011
Revision Received:
August 11 2011
Accepted:
August 11 2011
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem J (2012) 441 (2): 553–569.
Article history
Received:
February 14 2011
Revision Received:
August 11 2011
Accepted:
August 11 2011
Citation
Yves Romeo, Xiaocui Zhang, Philippe P. Roux; Regulation and function of the RSK family of protein kinases. Biochem J 15 January 2012; 441 (2): 553–569. doi: https://doi.org/10.1042/BJ20110289
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