More than 10 years after their first isolation, human embryonic stem cells are finally ‘coming of age’ in research and biotechnology applications as protocols for their differentiation and undifferentiated expansion in culture become robust and scalable, and validated commercial reagents become available. Production of human cardiomyocytes is now feasible on a daily basis for many laboratories with tissue culture expertise. An additional recent surge of interest resulting from the first production of human iPSCs (induced pluripotent stem cells) from somatic cells of patients now makes these technologies of even greater importance since it is likely that (genetic) cardiac disease phenotypes can be captured in the cardiac derivatives of these cells. Although cell therapy based on replacing cardiomyocytes lost or dysfunctional owing to cardiac disease are probably as far away as ever, biotechnology and pharmaceutical applications in safety pharmacology and drug discovery will probably impact this clinical area in the very near future. In the present paper, we review the cutting edge of this exciting area of translational research.
Skip Nav Destination
Article navigation
February 2011
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
Review Article|
January 27 2011
Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models
Cheryl Dambrot;
Cheryl Dambrot
*Department of Anatomy & Embryology, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands
†Department of Cardiology, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands
Search for other works by this author on:
Robert Passier;
Robert Passier
*Department of Anatomy & Embryology, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands
Search for other works by this author on:
Douwe Atsma;
Douwe Atsma
†Department of Cardiology, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands
Search for other works by this author on:
Christine L. Mummery
Christine L. Mummery
1
*Department of Anatomy & Embryology, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands
1To whom correspondence should be addressed (email c.l.mummery@lumc.nl).
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
October 19 2010
Revision Received:
November 08 2010
Accepted:
November 10 2010
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem J (2011) 434 (1): 25–35.
Article history
Received:
October 19 2010
Revision Received:
November 08 2010
Accepted:
November 10 2010
Citation
Cheryl Dambrot, Robert Passier, Douwe Atsma, Christine L. Mummery; Cardiomyocyte differentiation of pluripotent stem cells and their use as cardiac disease models. Biochem J 15 February 2011; 434 (1): 25–35. doi: https://doi.org/10.1042/BJ20101707
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.