The ability to store energy in the form of energy-dense TAG (triacylglycerol) and to mobilize these stores rapidly during times of low carbohydrate availability (fasting or famine) or during heightened metabolic demand (exercise or cold-stress) is a highly conserved process essential for survival. Today, in the presence of nutrient excess and sedentary lifestyles, the regulation of this pathway is viewed as an important therapeutic target for disease prevention, as elevated circulating fatty acids in obesity contribute to many aspects of the metabolic syndrome including hepatic steatosis, atherosclerosis and insulin resistance. In the present review, we discuss the metabolic regulation and function of TAG lipases with a focus on HSL (hormone-sensitive lipase), ATGL (adipose triacylglycerol lipase) and newly identified members of the lipolytic proteome.
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Review Article|
August 27 2008
Regulation and function of triacylglycerol lipases in cellular metabolism
Matthew J. Watt;
Matthew J. Watt
*Department of Physiology, Monash University, Clayton, VIC 3800, Australia
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Gregory R. Steinberg
Gregory R. Steinberg
1
†St. Vincent's Institute and Department of Medicine, University of Melbourne, Melbourne, VIC 3065, Australia
1To whom correspondence should be addressed (email gsteinberg@svi.edu.au).
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Publisher: Portland Press Ltd
Received:
February 05 2008
Revision Received:
May 15 2008
Accepted:
May 19 2008
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem J (2008) 414 (3): 313–325.
Article history
Received:
February 05 2008
Revision Received:
May 15 2008
Accepted:
May 19 2008
Citation
Matthew J. Watt, Gregory R. Steinberg; Regulation and function of triacylglycerol lipases in cellular metabolism. Biochem J 15 September 2008; 414 (3): 313–325. doi: https://doi.org/10.1042/BJ20080305
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