Recent advances in our understanding of both the regulation of components of the translational machinery and the upstream signalling pathways that modulate them have provided important new insights into the mechanisms by which hormones, growth factors, nutrients and cellular energy status control protein synthesis in mammalian cells. The importance of proper control of mRNA translation is strikingly illustrated by the fact that defects in this process or its control are implicated in a number of disease states, such as cancer, tissue hypertrophy and neurodegeneration. Signalling pathways such as those involving mTOR (mammalian target of rapamycin) and mitogen-activated protein kinases modulate the phosphorylation of translation factors, the activities of the protein kinases that act upon them and the association of RNA-binding proteins with specific mRNAs. These effects contribute both to the overall control of protein synthesis (which is linked to cell growth) and to the modulation of the translation or stability of specific mRNAs. However, important questions remain about both the contributions of individual regulatory events to the control of general protein synthesis and the mechanisms by which the translation of specific mRNAs is controlled.
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April 2007
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Review Article|
March 26 2007
Signalling to translation: how signal transduction pathways control the protein synthetic machinery
Christopher G. Proud
Christopher G. Proud
1
1Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
1email cgpr@interchange.ubc.ca
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Publisher: Portland Press Ltd
Received:
January 03 2007
Revision Received:
February 07 2007
Accepted:
February 08 2007
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Authors Journal compilation, The Biochemical Society, London
2007
Biochem J (2007) 403 (2): 217–234.
Article history
Received:
January 03 2007
Revision Received:
February 07 2007
Accepted:
February 08 2007
Citation
Christopher G. Proud; Signalling to translation: how signal transduction pathways control the protein synthetic machinery. Biochem J 15 April 2007; 403 (2): 217–234. doi: https://doi.org/10.1042/BJ20070024
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