Biological timekeeping is determined by internal temporal programmes and the resetting of these programmes or clocks by external stimuli. Many of the core genes of the mammalian daily or circadian clock are known, but the factors regulating so-called ‘clock’ gene proteins are unclear. In this issue of the Biochemical Journal, Gallego and colleagues show for the first time that protein phosphatase 1 plays a major role in the stability of mammalian PER2, a key protein in the core clock works. This contrasts somewhat with circadian rhythm control in the fruitfly Drosophila and the fungus Neurospora where current evidence supports a role for protein phosphatase 2A in core timekeeping. The mechanisms underpinning these actions of phosphatase 1 are unclear, and future investigations will need to identify the regulatory subunit that targets phosphatase 1 to mammalian PER2 (Period 2).
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September 13 2006
Stabilizing daily clock proteins
Hugh D. Piggins
Hugh D. Piggins
1
1Faculty of Life Sciences, University of Manchester, 3.614 Stopford Building, Oxford Road, Manchester M13 9PT, U.K.
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Publisher: Portland Press Ltd
Received:
August 08 2006
Revision Received:
August 11 2006
Accepted:
August 14 2006
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London
2006
Biochem J (2006) 399 (1): e1.
Article history
Received:
August 08 2006
Revision Received:
August 11 2006
Accepted:
August 14 2006
Connected Content
This is a correction to:
Protein phosphatase 1 regulates the stability of the circadian protein PER2
Citation
Hugh D. Piggins; Stabilizing daily clock proteins. Biochem J 1 October 2006; 399 (1): e1. doi: https://doi.org/10.1042/BJ20061211
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