The pathogenesis of anthrax is such that unless antibiotic treatment is initiated at an early stage in the disease, it is ineffective against the bacteria-induced toxaemia that subverts the immune response, inflicts massive tissue damage and is ultimately the major factor contributing to death during anthrax infection. As current events have demonstrated the feasibility of the use of anthrax as a bioterrorism agent, and exemplified the difficulty of treating the ensuing infection, inhibition of anthrax toxin has become a major focus of research for the design of antitoxin therapeutics. In this issue of Biochemical Journal, Bracci and co-workers describe the discovery by competitive screening of a phage-display library of a peptide inhibitor of anthrax toxin assembly that shows great promise towards the treatment of anthrax.
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April 2006
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March 15 2006
Peptide inhibitors MAP the way towards fighting anthrax pathogenesis
Aimee M. deCathelineau;
Aimee M. deCathelineau
1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, U.S.A.
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Gary M. Bokoch
Gary M. Bokoch
1
1Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, U.S.A.
1To whom correspondence should be addressed (email bokoch@scripps.edu).
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Publisher: Portland Press Ltd
Received:
February 13 2006
Accepted:
February 14 2006
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London
2006
Biochem J (2006) 395 (1): e1.
Article history
Received:
February 13 2006
Accepted:
February 14 2006
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Citation
Aimee M. deCathelineau, Gary M. Bokoch; Peptide inhibitors MAP the way towards fighting anthrax pathogenesis. Biochem J 1 April 2006; 395 (1): e1. doi: https://doi.org/10.1042/BJ20060245
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