The six members of the insulin-like growth factor-binding protein family (IGFBP-1–6) are important components of the IGF (insulin-like growth factor) axis. In this capacity, they serve to regulate the activity of both IGF-I and -II polypeptide growth factors. The IGFBPs are able to enhance or inhibit the activity of IGFs in a cell- and tissue-specific manner. One of these proteins, IGFBP-5, also has an important role in controlling cell survival, differentiation and apoptosis. In this review, we report on the structural and functional features of the protein which are important for these effects. We also examine the regulation of IGFBP-5 expression and comment on its potential role in tumour biology, with special reference to work with breast cancer cells.
Skip Nav Destination
Article navigation
April 2006
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
Review Article|
March 15 2006
Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis
James Beattie;
James Beattie
1
1Hannah Research Institute, Ayr KA6 5HL, Scotland, U.K.
1To whom correspondence should be addressed (email j.beattie@hannah.ac.uk).
Search for other works by this author on:
Gordon J. Allan;
Gordon J. Allan
1Hannah Research Institute, Ayr KA6 5HL, Scotland, U.K.
Search for other works by this author on:
Jennifer D. Lochrie;
Jennifer D. Lochrie
1Hannah Research Institute, Ayr KA6 5HL, Scotland, U.K.
Search for other works by this author on:
David J. Flint
David J. Flint
1Hannah Research Institute, Ayr KA6 5HL, Scotland, U.K.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
January 11 2006
Accepted:
January 30 2006
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London
2006
Biochem J (2006) 395 (1): 1–19.
Article history
Received:
January 11 2006
Accepted:
January 30 2006
Citation
James Beattie, Gordon J. Allan, Jennifer D. Lochrie, David J. Flint; Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis. Biochem J 1 April 2006; 395 (1): 1–19. doi: https://doi.org/10.1042/BJ20060086
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.