The cAMP signalling pathway has emerged as a key regulator of haematopoietic cell proliferation, differentiation and apoptosis. In parallel, general understanding of the biology of cyclic nucleotide PDEs (phosphodiesterases) has advanced considerably, revealing the remarkable complexity of this enzyme system that regulates the amplitude, kinetics and location of intracellular cAMP-mediated signalling. The development of therapeutic inhibitors of specific PDE gene families has resulted in a growing appreciation of the potential therapeutic application of PDE inhibitors to the treatment of immune-mediated illnesses and haematopoietic malignancies. This review summarizes the expression and function of PDEs in normal haematopoietic cells and the evidence that family-specific inhibitors will be therapeutically useful in myeloid and lymphoid malignancies.
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January 2006
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Review Article|
December 12 2005
Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies
Adam Lerner;
Adam Lerner
*Evans Department of Medicine, Section of Hematology and Oncology, Boston Medical Center, Boston, MA 02118, U.S.A.
†Department of Pathology, Boston University School of Medicine, Boston, MA 02118, U.S.A.
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Paul M. Epstein
Paul M. Epstein
1
‡Department of Pharmacology, University of Connecticut Health Center, Farmington, CT 06030, U.S.A.
1To whom correspondence should be addressed (email epstein@nso1.uchc.edu).
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Publisher: Portland Press Ltd
Received:
August 22 2005
Revision Received:
September 26 2005
Accepted:
October 04 2005
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London
2006
Biochem J (2006) 393 (1): 21–41.
Article history
Received:
August 22 2005
Revision Received:
September 26 2005
Accepted:
October 04 2005
Citation
Adam Lerner, Paul M. Epstein; Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies. Biochem J 1 January 2006; 393 (1): 21–41. doi: https://doi.org/10.1042/BJ20051368
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