PPD (PAZ Piwi domain) proteins and the Dicer family have been the subjects of intense study over the last 6 years. These proteins have well-established roles in RNAi (RNA interference), a process that relies on siRNAs (small interfering RNAs) or miRNAs (microRNAs) to mediate specificity. The development of techniques for applying RNAi as a laboratory tool and a molecular therapeutic technique has rapidly outpaced our understanding of the biology of this process. However, over the last 2 years, great strides have been made towards elucidating how PPD proteins and Dicer regulate gene-silencing at the pre- and post-transcriptional levels. In addition, evidence is beginning to emerge that suggests that these proteins have additional siRNA-independent roles as cell-cycle regulators. In the present review, we summarize the well-known roles of these two classes of proteins in gene-silencing pathways, as well as explore the evidence for novel roles of PPD and Dicer proteins.
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May 2005
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Review Article|
April 26 2005
Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others?
Katarzyna JARONCZYK;
Katarzyna JARONCZYK
1
*Department of Cell Biology, University of Alberta, Edmonton, AB, Canada T6G 2H7
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Jon B. CARMICHAEL;
Jon B. CARMICHAEL
1
*Department of Cell Biology, University of Alberta, Edmonton, AB, Canada T6G 2H7
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Tom C. HOBMAN
Tom C. HOBMAN
2
*Department of Cell Biology, University of Alberta, Edmonton, AB, Canada T6G 2H7
†Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada T6G 2H7
2To whom correspondence should be addressed (email Tom.Hobman@ualberta.ca).
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Publisher: Portland Press Ltd
Received:
November 01 2004
Revision Received:
December 23 2004
Accepted:
February 22 2005
Accepted Manuscript online:
April 26 2005
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London
2005
Biochem J (2005) 387 (3): 561–571.
Article history
Received:
November 01 2004
Revision Received:
December 23 2004
Accepted:
February 22 2005
Accepted Manuscript online:
April 26 2005
Citation
Katarzyna JARONCZYK, Jon B. CARMICHAEL, Tom C. HOBMAN; Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others?. Biochem J 1 May 2005; 387 (3): 561–571. doi: https://doi.org/10.1042/BJ20041822
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