One of the foremost challenges in the post-genomic era will be to chart the gene regulatory networks of cells, including aspects such as genome annotation, identification of cis-regulatory elements and transcription factors, information on protein–DNA and protein–protein interactions, and data mining and integration. Some of these broad sets of data have already been assembled for building networks of gene regulation. Even though these datasets are still far from comprehensive, and the approach faces many important and difficult challenges, some strategies have begun to make connections between disparate regulatory events and to foster new hypotheses. In this article we review several different genomics and proteomics technologies, and present bioinformatics methods for exploring these data in order to make novel discoveries.
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July 2004
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Review Article|
June 22 2004
Charting gene regulatory networks: strategies, challenges and perspectives
Gong-Hong WEI;
Gong-Hong WEI
1National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005, P.R. China
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De-Pei LIU;
De-Pei LIU
1
1National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005, P.R. China
1To whom correspondence should be addressed (e-mail liudp@pumc.edu.cn).
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Chih-Chuan LIANG
Chih-Chuan LIANG
1National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), 5 Dong Dan San Tiao, Beijing 100005, P.R. China
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Publisher: Portland Press Ltd
Received:
February 27 2004
Revision Received:
April 13 2004
Accepted:
April 13 2004
Accepted Manuscript online:
April 13 2004
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London
2004
Biochem J (2004) 381 (1): 1–12.
Article history
Received:
February 27 2004
Revision Received:
April 13 2004
Accepted:
April 13 2004
Accepted Manuscript online:
April 13 2004
Citation
Gong-Hong WEI, De-Pei LIU, Chih-Chuan LIANG; Charting gene regulatory networks: strategies, challenges and perspectives. Biochem J 1 July 2004; 381 (1): 1–12. doi: https://doi.org/10.1042/BJ20040311
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