The Drosophila gene grainyhead is the founding member of a large family of genes encoding developmental transcription factors that are highly conserved from fly to human. The family consists of two main branches, with grainyhead as the ancestral gene for one branch and the recently cloned DrosophilaCP2 as the ancestral gene for the other. We now extend this family with the identification of another novel mammalian member, Sister-of-Mammalian Grainyhead (SOM), which is phylogenetically aligned with grainyhead. SOM is closely related to the other mammalian homologues of grainyhead, including Mammalian Grainyhead (MGR) and Brother-of-MGR, sharing a high degree of sequence identity with these factors in the functional DNA-binding, protein dimerization and activation domains. Protein interaction studies demonstrate that SOM can heterodimerize with MGR and Brother-of-MGR, but not with the more distant members of the family. Like grainyhead, the SOM gene too produces several distinct isoforms with differing functional properties through alternative splicing. The tissue distributions of these isoforms differ and all display highly restricted expression patterns. These findings indicate that SOM, like its family members, may play important roles in mammalian development.
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March 2003
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Research Article|
March 15 2003
The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors
Stephen B. TING;
Stephen B. TING
∗Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital Research Foundation, c/o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria 3050, Australia,
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Tomasz WILANOWSKI;
Tomasz WILANOWSKI
∗Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital Research Foundation, c/o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria 3050, Australia,
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Loretta CERRUTI;
Loretta CERRUTI
∗Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital Research Foundation, c/o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria 3050, Australia,
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Lin-Lin ZHAO;
Lin-Lin ZHAO
∗Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital Research Foundation, c/o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria 3050, Australia,
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John M. CUNNINGHAM;
John M. CUNNINGHAM
†Division of Experimental Hematology, St Jude Children's Research Hospital, Memphis, TN 38101, U.S.A.
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Stephen M. JANE
Stephen M. JANE
1
∗Rotary Bone Marrow Research Laboratories, Royal Melbourne Hospital Research Foundation, c/o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, Victoria 3050, Australia,
1To whom correspondence should be addressed (e-mail jane@wehi.edu.au).
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Publisher: Portland Press Ltd
Received:
September 23 2002
Revision Received:
November 19 2002
Accepted:
December 09 2002
Accepted Manuscript online:
March 15 2003
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London ©2003
2003
Biochem J (2003) 370 (3): 953–962.
Article history
Received:
September 23 2002
Revision Received:
November 19 2002
Accepted:
December 09 2002
Accepted Manuscript online:
March 15 2003
Citation
Stephen B. TING, Tomasz WILANOWSKI, Loretta CERRUTI, Lin-Lin ZHAO, John M. CUNNINGHAM, Stephen M. JANE; The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors. Biochem J 15 March 2003; 370 (3): 953–962. doi: https://doi.org/10.1042/bj20021476
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