The Ca2+-binding synaptic-vesicle protein synaptotagmin I has attracted considerable interest as a potential Ca2+ sensor that regulates exocytosis from neurons and neuroendocrine cells. Recent studies have shed new light on the structure, biochemical/biophysical properties and function of synaptotagmin, and the emerging view is that it plays an important role in both exocytosis and endocytosis. At least a dozen additional isoforms exist, some of which are expressed outside of the nervous system, suggesting that synaptotagmins might regulate membrane traffic in a variety of cell types. Here we provide an overview of the members of this gene family, with particular emphasis on the question of whether and how synaptotagmin I functions during the final stages of membrane fusion: does it regulate the Ca2+-triggered opening and dilation of fusion pores?
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Review Article|
August 15 2002
Role of synaptotagmin in Ca2+-triggered exocytosis
Ward C. TUCKER;
Ward C. TUCKER
Department of Physiology, SMI 129, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, U.S.A.
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Edwin R. CHAPMAN
Edwin R. CHAPMAN
1
Department of Physiology, SMI 129, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, U.S.A.
1To whom correspondence should be addressed (e-mail chapman@physiology.wisc.edu).
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Publisher: Portland Press Ltd
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London ©2002
2002
Biochem J (2002) 366 (1): 1–13.
Citation
Ward C. TUCKER, Edwin R. CHAPMAN; Role of synaptotagmin in Ca2+-triggered exocytosis. Biochem J 15 August 2002; 366 (1): 1–13. doi: https://doi.org/10.1042/bj20020776
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