Phosphoinositides are key regulators of diverse cellular processes. The pleckstrin homology (PH) domain mediates the action of PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3, while the FYVE domain relays the pulse of PtdIns3P. The recent establishment that the Phox homology (PX) domain interacts with PtdIns3P and other phosphoinositides suggests another mechanism by which phosphoinositides can regulate/integrate multiple cellular events via a spectrum of PX domain-containing proteins. Together with the recent discovery that the epsin N-terminal homologue (ENTH) domain interacts with PtdIns(4,5)P2, it is becoming clear that phosphoinositides regulate diverse cellular events through interactions with several distinct structural motifs present in many different proteins.
Skip Nav Destination
Article navigation
Review Article|
December 10 2001
The Phox homology (PX) domain, a new player in phosphoinositide signalling
Yue XU;
Yue XU
Membrane Biology Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
Search for other works by this author on:
Li-Fong SEET;
Li-Fong SEET
Membrane Biology Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
Search for other works by this author on:
Brendon HANSON;
Brendon HANSON
Membrane Biology Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
Search for other works by this author on:
Wanjin HONG
Wanjin HONG
1
Membrane Biology Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
1To whom correspondence should be addressed (e-mail mcbhwj@imcb.nus.edu.sg).
Search for other works by this author on:
Publisher: Portland Press Ltd
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London ©2001
2001
Biochem J (2001) 360 (3): 513–530.
Citation
Yue XU, Li-Fong SEET, Brendon HANSON, Wanjin HONG; The Phox homology (PX) domain, a new player in phosphoinositide signalling. Biochem J 15 December 2001; 360 (3): 513–530. doi: https://doi.org/10.1042/bj3600513
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.