Long-chain acyl-CoA esters have potent specific actions (e.g. on gene transcription, membrane trafficking) as well as non-specific ones (e.g. on phospholipid bilayers). They are synthesized on the cytosolic aspects of several intracellular membranes, to give rise to (a) cytosolic pool(s) to which a variety of enzymes and processes have access, including some localized in the nucleus. Their concentration in cells is highly regulated, interconversion with corresponding acylcarnitines being the most important mechanism involved. This reaction is catalysed by cytosol-accessible carnitine long-chain acyl (palmitoyl) transferase activities that are themselves located on multiple membrane systems. Regulation of these activities is through the inhibitory action of malonyl-CoA. Hence the existence of a potent malonyl-CoA-acyl-CoA axis through which many processes involved in the maintenance of mammalian cell function are regulated. The molecular, topographical and physiological interactions that make this possible are described and discussed.
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November 1999
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Review Article|
October 25 1999
The malonyl-CoA–long-chain acyl-CoA axis in the maintenance of mammalian cell function
Victor A. ZAMMIT
Victor A. ZAMMIT
1
1Cell Biochemistry, Hannah Research Institute, Ayr, KA6 5HL, Scotland, U.K.
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Publisher: Portland Press Ltd
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London © 1999
1999
Biochem J (1999) 343 (3): 505–515.
Citation
Victor A. ZAMMIT; The malonyl-CoA–long-chain acyl-CoA axis in the maintenance of mammalian cell function. Biochem J 1 November 1999; 343 (3): 505–515. doi: https://doi.org/10.1042/bj3430505
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