Using virtual screening and biological assays, we have identified and characterized a new class of compounds that selectively inhibit the proliferation of cancer cells containing constitutively active kinase signalling pathways by targeting kinase regulation of oncogenic transcription factors.

Keywords:
activator protein-1, ATP-independent inhibitors, extracellular-signal-regulated kinases 1 and 2 (ERK1/2), in silico design, melanoma, mitogen-activated protein kinase (MAPK)
© The Authors Journal compilation © 2015 Biochemical Society
2015
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