The Nuclear Casein and Cyclin-dependent Kinase Substrate 1 (NUCKS1) protein is highly conserved in vertebrates, predominantly localized to the nucleus and one of the most heavily modified proteins in the human proteome. NUCKS1 expression is high in stem cells and the brain, developmentally regulated in mice and associated with several diverse malignancies in humans, including cancer, metabolic syndrome and Parkinson's disease. NUCKS1 function has been linked to modulating chromatin architecture and transcription, DNA repair and cell cycle regulation. In this review, we summarize and discuss the published information on NUCKS1 and highlight the questions that remain to be addressed to better understand the complex biology of this multifaceted protein.
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Cover Image
Cover Image
The cover image shows the crystal structure of AMPK a2b1g1 complexed with the pan activator MSG011. The inset surface representation details architecture of the MSG011 binding site, formed between the AMPK alpha-kinase domain (green) and beta-carbohydrate binding module (CBM, cyan). Explore more with Ovens and colleagues, “Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator” on pages 1181-1204.
NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes
Anne Carine Østvold, Kirsten Grundt, Claudia Wiese; NUCKS1 is a highly modified, chromatin-associated protein involved in a diverse set of biological and pathophysiological processes. Biochem J 17 June 2022; 479 (11): 1205–1220. doi: https://doi.org/10.1042/BCJ20220075
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