This commentary discusses general concepts introduced in the article ‘Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae’ by Montella-Manuel et al. (Biochem J (2021) 478: 811–837). Montella-Manuel et al. show that like central carbon metabolism, iron metabolism is also closely implicated in autophagy-mediated life extension via the TORC2 activator Ypk1p and the iron regulator Aft1p. While not being an iron-sulfur cluster protein, Aft1p interacts with such proteins and thus senses the redox status of the cell, which, similar to amino acids and AMP, reports its energetic status. Furthermore, glucose and iron deficiencies are interrelated as the diauxic shift in glucose depleted cells requires iron uptake for activating respiration in the absence of fermentation.
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May 2021
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Amphisomes are intermediate/hybrid organelles produced through the fusion of endosomes with autophagosomes within cells. In this issue Ganesan and Cai (pp. 1959–1976) provide an updated overview of the recent discoveries and advancements on the molecular and cellular mechanisms underlying amphisome biogenesis and the emerging roles of amphisomes. The image shows amphisome retrograde transport in the axons of neurons. Image courtesy of Qian Cai.
Commentary|
May 24 2021
Casting iron into the cell fate mold
Or Kakhlon
Department of Neurology, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem 91120, Israel
Correspondence: Or Kakhlon (ork@hadassah.org.il)
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Publisher: Portland Press Ltd
Received:
March 24 2021
Revision Received:
April 29 2021
Accepted:
May 04 2021
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2021
Biochem J (2021) 478 (10): 1879–1883.
Article history
Received:
March 24 2021
Revision Received:
April 29 2021
Accepted:
May 04 2021
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Citation
Or Kakhlon; Casting iron into the cell fate mold. Biochem J 28 May 2021; 478 (10): 1879–1883. doi: https://doi.org/10.1042/BCJ20210108
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