Regulation of metabolic pathways by signal transduction and transcriptional cascades can alter cellular levels of metabolites. Metabolites themselves can also have regulatory activity as shown in a new study published in the Biochemical Journal. Tsuchiya et al. describe a novel antibody and mass spectrometry-based method for identifying proteins that are reversibly modified with Coenzyme A (CoA). Analysis of the ‘CoAlated proteome’ under conditions of oxidative and metabolic stress revealed a bias towards the modification of metabolic enzymes by CoA. Furthermore, CoAlation was shown to alter the activity of target proteins. These results suggest that CoAlation is a widespread post-translational modification that may have important roles in the metabolic response to stress.
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August 2017
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The distribution of haemagglutinin (green) and β-catenin (red) in MDCK cells overexpressing Akt1-HA. In this issue of the Biochemical Journal, Castañeda et al. report on the suppression of Akt/β-catenin-mediated cell proliferation by the the inhibition of 14-3-3ζ expression (see pages 2679–2689).
Commentary|
August 10 2017
Protein CoAlation: a redox-linked post-translational modification
Steven C. Ley;
Steven C. Ley
1The Francis Crick Institute, London, U.K.
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Luiz Pedro S. de Carvalho
1The Francis Crick Institute, London, U.K.
Correspondence: Steven C. Ley (steve.ley@crick.ac.uk) and Luiz Pedro S. de Carvalho (luiz.carvalho@crick.ac.uk)
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Publisher: Portland Press Ltd
Received:
June 23 2017
Revision Received:
July 05 2017
Accepted:
July 05 2017
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
2017
Biochem J (2017) 474 (16): 2897–2899.
Article history
Received:
June 23 2017
Revision Received:
July 05 2017
Accepted:
July 05 2017
Connected Content
This is a commentary on:
Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells
Citation
Steven C. Ley, Luiz Pedro S. de Carvalho; Protein CoAlation: a redox-linked post-translational modification. Biochem J 15 August 2017; 474 (16): 2897–2899. doi: https://doi.org/10.1042/BCJ20170168
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