PAK4 [p21 protein (Cdc42/Rac)-activated kinase 4] and partitioning defective (Par) 6B are required for apical junction assembly in epithelial cells. PAK4 phosphorylates Par6B at Ser143 blocking its interaction with Cdc42 (cell division cycle 42). This could provide dynamic turnover of Par6B at junctions and/or promote Par6B interactions with alternative binding partners.
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Research Article| April 02 2015
Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4
*Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, U.S.A.
†Cell & Developmental Biology Graduate Program, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, U.S.A.
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Dan Jin, Joanne Durgan, Alan Hall; Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4. Biochem J 15 April 2015; 467 (2): 293–302. doi: https://doi.org/10.1042/BJ20141352
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