Membrane-bound pyrophosphatases (mPPases) couple pyrophosphate (PPi) hydrolysis to H+ and/or Na+ transport. In the present study, we describe a novel subfamily of H+-transporting mPPases that are only distantly related to known mPPases and show an unusual pattern of regulation by Na+ and K+.

Keywords:
enzyme regulation, membrane transport, protein evolution, proton pump, proton transport, pyrophosphatase
© The Authors Journal compilation © 2015 Biochemical Society
2015
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