We have elucidated the molecular effects of nine cancer-associated somatic mutations of Keap1, an important regulator of the Nrf2-mediated oxidative stress response, on the structural integrity and target recognition properties of the protein by using multiple biophysical techniques.

Keywords:
isothermal titration calorimetry, nuclear factor erythroid 2-related factor 2 (Nrf2), nuclear magnetic resonance, oxidative stress response, prothymosin α
© The Authors Journal compilation © 2015 Biochemical Society
2015
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