Class II isoforms of PI3K (phosphoinositide 3-kinase) are still the least investigated and characterized of all PI3Ks. In the last few years, an increased interest in these enzymes has improved our understanding of their cellular functions. However, several questions still remain unanswered on their mechanisms of activation, their specific downstream effectors and their contribution to physiological processes and pathological conditions. Emerging evidence suggests that distinct PI3Ks activate different signalling pathways, indicating that their functional roles are probably not redundant. In the present review, we discuss the recent advances in our understanding of mammalian class II PI3Ks and the evidence suggesting their involvement in human diseases.
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Review Article|
April 16 2012
Regulation and cellular functions of class II phosphoinositide 3-kinases
Marco Falasca;
Marco Falasca
1
1Inositide Signalling Group, Centre for Diabetes, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, U.K.
1To whom correspondence should be addressed (email m.falasca@qmul.ac.uk).
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Tania Maffucci
Tania Maffucci
1Inositide Signalling Group, Centre for Diabetes, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, U.K.
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Publisher: Portland Press Ltd
Received:
January 09 2012
Revision Received:
February 29 2012
Accepted:
March 01 2012
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2012 Biochemical Society
2012
Biochem J (2012) 443 (3): 587–601.
Article history
Received:
January 09 2012
Revision Received:
February 29 2012
Accepted:
March 01 2012
Citation
Marco Falasca, Tania Maffucci; Regulation and cellular functions of class II phosphoinositide 3-kinases. Biochem J 1 May 2012; 443 (3): 587–601. doi: https://doi.org/10.1042/BJ20120008
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