The mitochondrial CIC (citrate carrier) catalyses the efflux of citrate from the mitochondrial matrix in exchange for cytosolic malate. In the present paper we show that CIC mRNA and protein markedly increase in lipopolysaccharide-activated immune cells. Moreover, CIC gene silencing and CIC activity inhibition significantly reduce production of NO, reactive oxygen species and prostaglandins. These results demonstrate for the first time that CIC has a critical role in inflammation.

Keywords:
citrate carrier (CIC), gene regulation, immune cell, nitric oxide (NO), prostaglandin E2, reactive oxygen species (ROS)
© The Authors Journal compilation © 2011 Biochemical Society
2011
You do not currently have access to this content.