Mitosis is associated with profound changes in cell physiology and a spectacular surge in protein phosphorylation. To accomplish these, a remarkably large portion of the kinome is involved in the process. In the present review, we will focus on classic mitotic kinases, such as cyclin-dependent kinases, Polo-like kinases and Aurora kinases, as well as more recently characterized players such as NIMA (never in mitosis in Aspergillus nidulans)-related kinases, Greatwall and Haspin. Together, these kinases co-ordinate the proper timing and fidelity of processes including centrosomal functions, spindle assembly and microtubule–kinetochore attachment, as well as sister chromatid separation and cytokinesis. A recurrent theme of the mitotic kinase network is the prevalence of elaborated feedback loops that ensure bistable conditions. Sequential phosphorylation and priming phosphorylation on substrates are also frequently employed. Another important concept is the role of scaffolds, such as centrosomes for protein kinases during mitosis. Elucidating the entire repertoire of mitotic kinases, their functions, regulation and interactions is critical for our understanding of normal cell growth and in diseases such as cancers.
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Review Article|
March 15 2011
How protein kinases co-ordinate mitosis in animal cells
Hoi Tang Ma;
Hoi Tang Ma
1Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
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Randy Y. C. Poon
Randy Y. C. Poon
1
1Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
1To whom correspondence should be addressed (email rycpoon@ust.hk).
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Publisher: Portland Press Ltd
Received:
February 23 2010
Revision Received:
January 11 2011
Accepted:
January 13 2011
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2011 Biochemical Society
2011
Biochem J (2011) 435 (1): 17–31.
Article history
Received:
February 23 2010
Revision Received:
January 11 2011
Accepted:
January 13 2011
Citation
Hoi Tang Ma, Randy Y. C. Poon; How protein kinases co-ordinate mitosis in animal cells. Biochem J 1 April 2011; 435 (1): 17–31. doi: https://doi.org/10.1042/BJ20100284
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