From the realization that cell number homoeostasis is fundamental to the biology of all metazoans, and that deregulation of this process leads to human diseases, enormous interest has been devoted over the last two decades to map the requirements of cell death and cell survival. This effort has led to tangible progress, and we can now chart with reasonable accuracy complex signalling circuitries controlling cell-fate decisions. Some of this knowledge has translated into novel therapeutics, and the outcome of these strategies, especially in cancer, is eagerly awaited. However, the function of cell-death modifiers have considerably broadened over the last few years, and these molecules are increasingly recognized as arbiters of cellular homoeostasis, from cell division, to intracellular signalling to cellular adaptation. This panoply of functions is best exemplified by members of the IAP (inhibitor of apoptosis) gene family, molecules originally narrowly defined as endogenous caspase inhibitors, but now firmly positioned at the crossroads of multiple normal and transformed cellular responses.
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September 2010
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Review Article|
August 13 2010
Survivin and IAP proteins in cell-death mechanisms
Dario C. Altieri
1Prostate Cancer Discovery and Development Program, Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A.
1email dario.altieri@umassmed.edu
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Publisher: Portland Press Ltd
Received:
June 03 2010
Revision Received:
July 02 2010
Accepted:
July 06 2010
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem J (2010) 430 (2): 199–205.
Article history
Received:
June 03 2010
Revision Received:
July 02 2010
Accepted:
July 06 2010
Citation
Dario C. Altieri; Survivin and IAP proteins in cell-death mechanisms. Biochem J 1 September 2010; 430 (2): 199–205. doi: https://doi.org/10.1042/BJ20100814
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