The ε isoform of protein kinase C (PKCε) has important roles in the function of the cardiac, immune and nervous systems. As a result of its diverse actions, PKCε is the target of active drug-discovery programmes. A major research focus is to identify signalling cascades that include PKCε and the substrates that PKCε regulates. In the present review, we identify and discuss those proteins that have been conclusively shown to be direct substrates of PKCε by the best currently available means. We will also describe binding partners that anchor PKCε near its substrates. We review the consequences of substrate phosphorylation and discuss cellular mechanisms by which target specificity is achieved. We begin with a brief overview of the biology of PKCε and methods for substrate identification, and proceed with a discussion of substrate categories to identify common themes that emerge and how these may be used to guide future studies.
Skip Nav Destination
Article navigation
April 2010
-
Cover Image
Cover Image
- PDF Icon PDF LinkFront Matter
- PDF Icon PDF LinkTable of Contents
- PDF Icon PDF LinkEditorial Board
Review Article|
March 29 2010
The substrates and binding partners of protein kinase Cε
Philip M. Newton;
Philip M. Newton
1
*School of Medicine, Swansea University, Grove Building, Singleton Park Campus, Swansea SA2 8PP, Wales, U.K.
1To whom correspondence should be addressed (email p.newton@swansea.ac.uk).
Search for other works by this author on:
Robert O. Messing
Robert O. Messing
†Ernest Gallo Clinic and Research Center, Department of Neurology, University of California San Francisco, 5858 Horton Street, Emeryville, CA 94608, U.S.A.
Search for other works by this author on:
Publisher: Portland Press Ltd
Received:
August 20 2009
Revision Received:
January 25 2010
Accepted:
January 26 2010
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2010 Biochemical Society
2010
Biochem J (2010) 427 (2): 189–196.
Article history
Received:
August 20 2009
Revision Received:
January 25 2010
Accepted:
January 26 2010
Citation
Philip M. Newton, Robert O. Messing; The substrates and binding partners of protein kinase Cε. Biochem J 15 April 2010; 427 (2): 189–196. doi: https://doi.org/10.1042/BJ20091302
Download citation file:
Sign in
Don't already have an account? Register
Sign in to your personal account
You could not be signed in. Please check your email address / username and password and try again.
Captcha Validation Error. Please try again.