Obesity and diabetes are associated with increased fatty acid availability in excess of muscle fatty acid oxidation capacity. This mismatch is implicated in the pathogenesis of cardiac contractile dysfunction and also in the development of skeletal-muscle insulin resistance. We tested the hypothesis that ‘Western’ and high fat diets differentially cause maladaptation of cardiac- and skeletal-muscle fatty acid oxidation, resulting in cardiac contractile dysfunction. Wistar rats were fed on low fat, ‘Western’ or high fat (10, 45 or 60% calories from fat respectively) diet for acute (1 day to 1 week), short (4–8 weeks), intermediate (16–24 weeks) or long (32–48 weeks) term. Oleate oxidation in heart muscle ex vivo increased with high fat diet at all time points investigated. In contrast, cardiac oleate oxidation increased with Western diet in the acute, short and intermediate term, but not in the long term. Consistent with fatty acid oxidation maladaptation, cardiac power decreased with long-term Western diet only. In contrast, soleus muscle oleate oxidation (ex vivo) increased only in the acute and short term with either Western or high fat feeding. Fatty acid-responsive genes, including PDHK4 (pyruvate dehydrogenase kinase 4) and CTE1 (cytosolic thioesterase 1), increased in heart and soleus muscle to a greater extent with feeding a high fat diet compared with a Western diet. In conclusion, we implicate inadequate induction of a cassette of fatty acid-responsive genes, and impaired activation of fatty acid oxidation, in the development of cardiac dysfunction with Western diet.
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September 2007
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Research Article|
August 29 2007
Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats
Christopher R. Wilson;
Christopher R. Wilson
*Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 1.246, Houston, TX 77030, U.S.A.
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Mai K. Tran;
Mai K. Tran
*Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 1.246, Houston, TX 77030, U.S.A.
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Katrina L. Salazar;
Katrina L. Salazar
*Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 1.246, Houston, TX 77030, U.S.A.
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Martin E. Young;
Martin E. Young
†Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, U.S.A.
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Heinrich Taegtmeyer
Heinrich Taegtmeyer
1
*Department of Internal Medicine, Division of Cardiology, University of Texas Medical School at Houston, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 1.246, Houston, TX 77030, U.S.A.
1To whom correspondence should be addressed (email Heinrich.Taegtmeyer@uth.tmc.edu).
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Publisher: Portland Press Ltd
Received:
March 20 2007
Revision Received:
May 25 2007
Accepted:
June 06 2007
Accepted Manuscript online:
June 06 2007
Online ISSN: 1470-8728
Print ISSN: 0264-6021
© The Authors Journal compilation © 2007 Biochemical Society
2007
Biochem J (2007) 406 (3): 457–467.
Article history
Received:
March 20 2007
Revision Received:
May 25 2007
Accepted:
June 06 2007
Accepted Manuscript online:
June 06 2007
Citation
Christopher R. Wilson, Mai K. Tran, Katrina L. Salazar, Martin E. Young, Heinrich Taegtmeyer; Western diet, but not high fat diet, causes derangements of fatty acid metabolism and contractile dysfunction in the heart of Wistar rats. Biochem J 15 September 2007; 406 (3): 457–467. doi: https://doi.org/10.1042/BJ20070392
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