Small-molecule inhibitors are now widely used to try to dissect regulatory signalling events. Many of these interfere with the function of protein kinases, often as part of signalling cascades. In addition to their utility as tools for the researcher, the long-term aspiration is that certain of these compounds may be useful as therapeutic agents for the treatment of conditions that arise from the dysregulation of specific signalling pathways. In this issue of the Biochemical Journal, Sapkota and colleagues report the identification and initial validation of a compound that inhibits the RSK (p90 ribosomal S6 kinase) group of protein kinases, which are members of an important family of kinases (the ‘AGC kinases’) that have overlapping specificities.
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December 11 2006
A sharper instrument for dissecting signalling events: a specific AGC kinase inhibitor
Christopher G. Proud
Christopher G. Proud
1
1Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
1email cgpr@interchange.ubc.ca
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Publisher: Portland Press Ltd
Received:
November 10 2006
Accepted:
November 15 2006
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London
2007
Biochem J (2007) 401 (1): e1.
Article history
Received:
November 10 2006
Accepted:
November 15 2006
Connected Content
This is a correction to:
BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo
Citation
Christopher G. Proud; A sharper instrument for dissecting signalling events: a specific AGC kinase inhibitor. Biochem J 1 January 2007; 401 (1): e1. doi: https://doi.org/10.1042/BJ20061691
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