There has been ongoing controversy over the respective roles of insulin-like growth factor-1 receptors and insulin receptors in controlling insulin release from β-cells of the pancreas. An acute knock-down experiment exploiting small interfering RNA approaches provides a resolution: both are required.

Keywords:
glucose metabolism, insulin, insulin-like growth factor-1 (IGF1), pancreatic β-cells
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The Biochemical Society, London ©2004
2004
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