Members of the protein kinase C (PKC) family are expressed in many different cell types, where they are known to regulate a wide variety of cellular processes that impact on cell growth and differentiation, cytoskeletal remodelling and gene expression in the response to diverse stimuli. The broad tissue distribution and redundancy of in vitro function have often hampered the identification of definitive roles for each PKC family member. However, recent in vivo studies of PKC isoenzyme-selective knockout and transgenic mice have highlighted distinct functions of individual PKCs in the immune system. These genetic analyses, along with biochemical studies utilizing PKC isoenzyme-specific cDNA (wild-type, constitutively active and dominant-negative), antisense oligonucleotides (ASO), RNA interference (RNAi), and pharmacological inhibitors, indicate that PKC-regulated signalling pathways play a significant role in many aspects of immune responses, from development, differentiation, activation and survival of lymphocytes to macrophage activation. The importance of PKCs in cellular immune responses suggests that improved understanding of the molecular events that govern their actions could point to new avenues for development of treatments for immune disorders.
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Review Article| December 15 2003
Emerging and diverse roles of protein kinase C in immune cell signalling
Peter J. PARKER
Peter J. PARKER 1
†Protein Phosphorylation Laboratory, Cancer Research UK London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, London WC2A 3PX, U.K.
1To whom correspondence should be addressed (e-mail email@example.com).
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Publisher: Portland Press Ltd
Received: September 16 2003
Revision Received: October 20 2003
Accepted: October 22 2003
Accepted Manuscript online: October 22 2003
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London ©2003
Seng-Lai TAN, Peter J. PARKER; Emerging and diverse roles of protein kinase C in immune cell signalling. Biochem J 15 December 2003; 376 (3): 545–552. doi: https://doi.org/10.1042/bj20031406
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