Phosphorylation plays a central role in regulating the activation and signalling lifetime of protein kinases A, B (also known as Akt) and C. These kinases share three conserved phosphorylation motifs: the activation loop segment, the turn motif and the hydrophobic motif. This review focuses on how phosphorylation at each of these sites regulates the maturation, signalling and down-regulation of PKC as a paradigm for how these sites control the function of the ABC kinases.

Keywords:
phosphoinositide 3-kinase, phosphoinositide-dependent kinase-1 (PDK-1), phosphorylation motif, protein kinase A (PKA), protein kinase B (PKB)/Akt, protein kinase C (PKC)
This content is only available as a PDF.
The Biochemical Society, London ©2003
2003
You do not currently have access to this content.