A set of orthologous plasma proteins found in human, sheep, pig, cow and rodents, now collectively designated fetuin-A, constitutes the fetuin family. Fetuin-A has been identified as a major protein during fetal life and is also involved in important functions such as inhibition of the insulin receptor tyrosine kinase activity, protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. Furthermore, fetuin-A is a key partner in the recovery phase of an acute inflammatory response. We now describe a second protein of the fetuin family, called fetuin-B, which is found at least in human and rodents. On grounds of domain homology, overall conservation of cysteine residues and chromosomal assignments of the corresponding genes in these species, fetuin-B is unambiguously a paralogue of fetuin-A. Yet, fetuin-A and fetuin-B exhibit significant differences at the amino acid sequence level, notably including variations with respect to the archetypal fetuin-specific signature. Differences and similarities in terms of gene regulation were also observed. Indeed, studies performed during development in rat and mouse showed for the first time high expression of a member of the fetuin family in adulthood, as shown with the fetuin-B mRNA in rat. However, like its fetuin-A counterpart, the fetuin-B mRNA level is down-regulated during the acute phase of experimentally induced inflammation in rat.
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September 2000
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Research Article|
August 23 2000
Fetuin-B, a second member of the fetuin family in mammals
Emmanuel OLIVIER;
Emmanuel OLIVIER
*INSERM Unit-519 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides, Faculté de Médecine-Pharmacie, 22 Bvd Gambetta, 76183 Rouen Cedex, France
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Emmanuelle SOURY;
Emmanuelle SOURY
*INSERM Unit-519 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides, Faculté de Médecine-Pharmacie, 22 Bvd Gambetta, 76183 Rouen Cedex, France
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Philippe RUMINY;
Philippe RUMINY
*INSERM Unit-519 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides, Faculté de Médecine-Pharmacie, 22 Bvd Gambetta, 76183 Rouen Cedex, France
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Annie HUSSON;
Annie HUSSON
†“Appareil Digestif, Environnement et Nutrition” research group and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides, Faculté de Médecine-Pharmacie, Rouen, France
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Françoise PARMENTIER;
Françoise PARMENTIER
‡INSERM EPI 9906 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides, Faculté de Médecine-Pharmacie, Rouen, France
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Maryvonne DAVEAU;
Maryvonne DAVEAU
*INSERM Unit-519 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides, Faculté de Médecine-Pharmacie, 22 Bvd Gambetta, 76183 Rouen Cedex, France
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Jean-Philippe SALIER
Jean-Philippe SALIER
1
*INSERM Unit-519 and Institut Fédératif de Recherches Multidisciplinaires sur les Peptides, Faculté de Médecine-Pharmacie, 22 Bvd Gambetta, 76183 Rouen Cedex, France
1To whom correspondence should be addressed (e-mail Jean-Philippe.Salier@univ-rouen.fr).
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Publisher: Portland Press Ltd
Revision Received:
May 09 2000
Accepted:
June 08 2000
Received:
December 10 2000
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London © 2000
2000
Biochem J (2000) 350 (2): 589–597.
Article history
Revision Received:
May 09 2000
Accepted:
June 08 2000
Received:
December 10 2000
Citation
Emmanuel OLIVIER, Emmanuelle SOURY, Philippe RUMINY, Annie HUSSON, Françoise PARMENTIER, Maryvonne DAVEAU, Jean-Philippe SALIER; Fetuin-B, a second member of the fetuin family in mammals. Biochem J 1 September 2000; 350 (2): 589–597. doi: https://doi.org/10.1042/bj3500589
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