The architecture of cells, with various membrane-bound compartments and with the protein synthesizing machinery confined to one location, dictates that many proteins have to be transported through one or more membranes during their biogenesis. A lot of progress has been made on the identification of protein translocation machineries and their sorting signals in various organelles and organisms. Biochemical characterization has revealed the functions of several individual protein components. Interestingly, lipid components were also found to be essential for the correct functioning of these translocases. This led to the idea that there is a very intimate relationship between the lipid and protein components that enables them to fulfil their intriguing task of transporting large biopolymers through a lipid bilayer without leaking their contents. In this review we focus on the Sec translocases in the endoplasmic reticulum and the bacterial inner membrane. We also highlight the interactions of lipids and proteins during the process of translocation and integrate this into a model that enables us to understand the role of membrane lipid composition in translocase function.
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May 2000
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Review Article|
April 25 2000
Role of lipids in the translocation of proteins across membranes
Frank VAN VOORST;
Frank VAN VOORST
1
1To whom correspondence should be addressed (e-mail F.vanvoorst@;chem.uu.nl).
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Ben DE KRUIJFF
Ben DE KRUIJFF
1Department of Biochemistry of Membranes, CBLE, Institute Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
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Publisher: Portland Press Ltd
Online ISSN: 1470-8728
Print ISSN: 0264-6021
The Biochemical Society, London © 2000
2000
Biochem J (2000) 347 (3): 601–612.
Citation
Frank VAN VOORST, Ben DE KRUIJFF; Role of lipids in the translocation of proteins across membranes. Biochem J 1 May 2000; 347 (3): 601–612. doi: https://doi.org/10.1042/bj3470601
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