The 'Beginner's Guides' are an ongoing series of feature articles, each one covering a key technique and offering the scientifically literate, but not necessarily expert audience, a background briefing on the underlying science of a technique that is (or will be) widely used in molecular bioscience. The series will cover a mixture of techniques, including some that are well established amongst a subset of our readership but not necessarily familiar to those in different specialisms. This 'Beginner's Guide' covers nuclear magnetic resonance. Nuclear magnetic resonance (NMR) provides a way to explore the 3D structures of macromolecules in much more biologically relevant conditions and does this by taking advantage of the quantum mechanical property of some nuclei---nuclear spin. Here, we discuss how nuclear spin can be harnessed to provide information on the 3D structure of macromolecules in solution and how new thinking is leading to a revolution in drug discovery.
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Beginner's Guide|
June 01 2019
A beginner's guide to nuclear magnetic resonance: from atomic spies to complex 3D structures at the heart of structural biology
Timothy J. Woodman
Timothy J. Woodman
1University of Bath, UK
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Publisher: Portland Press Ltd
Online ISSN: 1740-1194
Print ISSN: 0954-982X
2019 © The Authors
2019
Published by Portland Press Limited under the Creative Commons Attribution License 4.0 (CC BY-NC-ND)
Biochem (Lond) (2019) 41 (3): 52–55.
Citation
Timothy J. Woodman; A beginner's guide to nuclear magnetic resonance: from atomic spies to complex 3D structures at the heart of structural biology. Biochem (Lond) 1 June 2019; 41 (3): 52–55. doi: https://doi.org/10.1042/BIO04103052
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