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May 2020
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In this issue of Clinical Science (volume 134, issue 10), Vaira et al. investigate the deregulation of miRNAs in the the transition from indolent celiac disease (upper image) to the refractory type 2 disease (RCD2; middle image) and full blown enteropathy-associated T-cell lymphoma (lower image). They found that upregulation of the C19MC and miR-17/92 miRNAs in RCD2 and lymphoma correlates with c-MYC/STAT3 signaling activity (brown nuclei), and that this pathway is blunted by Tofacitinib, a pan-JAK inhibitor.
ISSN 0143-5221
EISSN 1470-8736
In this Issue
Research Articles
Increased MUC1 plus a larger quantity and complex size for MUC5AC in the peripheral airway lumen of long-term tobacco smokers
Médea Padra; Anders Andersson; Bettina Levänen; Pushpa Premaratne; Helga Asgeirsdottir; Sara Tengvall; Karin Christenson; Marit Stockfelt; Steven Bozinovski; Shigemi Yoshihara; Ann-Sofie Lantz; Lena Palmberg; Barbro Dahlén; Kjell Larsson; Ingemar Qvarfordt; Sara K. Lindén; Anders Lindén
Clin Sci (Lond) (2020) 134 (10): 1107–1125.
Homocysteine induces melanocytes apoptosis via PERK–eIF2α–CHOP pathway in vitiligo
Jiaxi Chen; Tongtian Zhuang; Jianru Chen; Yangzi Tian; Xiuli Yi; Qingrong Ni; Weigang Zhang; Pu Song; Zhe Jian; Ling Liu; Tingting Cui; Kai Li; Tianwen Gao; Chunying Li; Shuli Li
Clin Sci (Lond) (2020) 134 (10): 1127–1141.
Deregulation of miRNAs-cMYC circuits is a key event in refractory celiac disease type-2 lymphomagenesis
Valentina Vaira; Gabriella Gaudioso; Maria Antonella Laginestra; Andrea Terrasi; Claudio Agostinelli; Silvano Bosari; Antonio Di Sabatino; Alessandro Vanoli; Marco Paulli; Stefano Ferrero; Leda Roncoroni; Vincenza Lombardo; Liyanage P. Perera; Sonia Fabris; Maurizio Vecchi; Stefano Pileri; Luca Elli
Clin Sci (Lond) (2020) 134 (10): 1151–1166.
Green tea polyphenols ameliorate metabolic abnormalities and insulin resistance by enhancing insulin signalling in skeletal muscle of Zucker fatty rats
Clin Sci (Lond) (2020) 134 (10): 1167–1180.
A novel rare c.-39C>T mutation in the PROS1 5′UTR causing PS deficiency by creating a new upstream translation initiation codon
Sylvie Labrouche-Colomer; Omar Soukarieh; Carole Proust; Christine Mouton; Yoann Huguenin; Maguelonne Roux; Céline Besse; Anne Boland; Robert Olaso; Joël Constans; Jean-François Deleuze; Pierre-Emmanuel Morange; Béatrice Jaspard-Vinassa; David-Alexandre Trégouët; on behalf of the GenMed Consortium
Clin Sci (Lond) (2020) 134 (10): 1181–1190.
Correspondence
Alternative splicing of ACE2 possibly generates variants that may limit the entry of SARS-CoV-2: a potential therapeutic approach using SSOs
Clin Sci (Lond) (2020) 134 (10): 1143–1150.
